Polynucleotide Rejuvenation
Banner Wording Revitalize Your Skin with revolutionary regenerative medicine.
New era of skin rejuvenation, an innovative treatment based on polymerized polynucleotides
Polynucleotides are a revolutionary regenerative medicine, offering a breakthrough in skin rejuvenation. These powerful treatments promote cell turnover, improve skin elasticity and hydration, and effectively heal damaged and ageing skin. By addressing concerns like wrinkles, fine lines, dark circles, pigmentation, acne-scaring and photoaging, polynucleotides deliver a nourished, healthy, and revitalized complexion. Ideal for those seeking advanced skincare solutions, polynucleotide therapy enhances your natural beauty with scientifically proven results, leaving your skin looking and feeling its best.
About Polynucleotide Rejuvenation:
Plinest® an injectable polynucleotide containing deoxyribonucleotide polymers (DNA chain) which is sterilised, ultra-purified product extracted from fish (Wild Salmon or Trout sperm)
The Science Behind it:
Fascinating science behind polynucleotide therapy. When injected, it causes a histological change of fibroblasts, osteoblasts, adipocytes and other tissues. This alters the structure of the fibroblast to become myofibroblasts, a phenotype that lies between the smooth muscle cells and fibroblasts. This transformation leads to a lift in the skin structure, visible smooth skin and youthfulness.
Benefits of Polynucleotides:
There are several benefits for your skin:
- Natural Rejuvenation: Harnessing the natural repair mechanism of the skin, polynucleotide provides a gentle yet effective approach to enhancing skin vitality.
- Targets Free Radical and Oxidative Stress: The treatment acts as a “scavenger” to neutralise free radicals and shield the skin from oxidative stress.
- Triggers and Improves Tissue Rejuvenation: The treatment initiates a variety of responses in the treated area, such as the recruitment of stem cells which has a strong repairing effect on
- Restores Skin Tone and Elasticity: Helps restore skin tone and elasticity, leaving your skin looking young and radiant. The use of polynucleotidespromotes the formation of new capillaries (angiogenesis), improving blood flow and skin health.
Area of Treatments with Polynucleotides:
Plinest is the leading brand of polynucleotides by Mastelli.
Plinest and Plinest Fast contain a gel with polynucleotides for intradermal injections to the face, neck, decolletage and hands. This treatment significantly improves skin hydration, plumps the skin, improves deep hollowness in the periorbital area, reduces fine lines and improves skin tone and elasticity.
The treatment enhances the production of collagen and elastin which helps to minimise fine lines and wrinkles, giving the skin a smoother, younger-looking texture and appearance. It is ideal for individuals who want a natural more youthful and refreshed look without the fillers.
Plinest Eye is a revolutionary eye care product designed to combat the signs of ageing and fatigue around the eye area, reduce eye bags, dark circles and periocular wrinkles. The hydrating formula ensures that the skin around the eyes remains moisturised and plump, preventing dryness and wrinkles. It's ideal for individuals seeking a targeted approach to eye care.
Plinest Hair is specifically formulated for hair and scalp rejuvenation to nourish and strengthen hair from the roots, promoting healthier, fuller and more resilient hair growth. The treatment goes beyond superficial care, it targets scalp health at a cellular level, addressing the root cause of hair thinning and loss, such as nutrient deficiencies and impact on environmental stressors. Plinest Hair intensive formula only aims to reduce hair loss but also stimulates new hair growth, resulting in a denser, more vibrant hair appearance.
Newest is a combination of polynucleotide and hyaluronic acid, specially formulated to target skin rejuvenation and hydration. This treatment boosts collagen synthesis and facilitates the repair of aged or damaged tissue, ideal for intensive care in specific areas providing a localised approach to skin rejuvenation. Resulting in remarkable improvement in skin texture and elasticity, and visibly more youthful complexion.
Treatment Procedure:
Initial Consultation:
The first step towards your skin rejuvenation is a consultation. During this session, a qualified medical practitioner will assess your skin, talk with you about your concerns and desired goals, and determine whether polynucleotide therapy is the best course of action. During the consultation the practitioner will discuss the potential risks, side effects and aftercare recommendations, this will help you determine if the treatment is right for you. Once agreed a personalised treatment plan is created to meet your specific requirements and expectations.
The Treatment Process:
To minimise the discomfort and maximise the effectiveness the medical practitioner will apply a numbing cream(topical anaesthetics) before the procedure. The skin is cleansed using Clinisept before the procedure. The clear gel is injected into the targeted area using ultrafine needles or cannula. The procedure can take from 30 to 60 minutes.
Aftercare and Follow-up
You will be given both verbal and written aftercare advice. After the treatment, you may notice swelling, bruising and raised red spots which will go down in the next 2-4 hours.
You will be advised for the next 6 hours to avoid touching the treated area, avoid makeup and drinking alcohol on the day of treatment. Keep your hands clean and avoid using your mobile phone against the treated area. Do not let pets lick your face and do not pick or scratch the treated area.
For the next 12-24 hours it is advisable to avoid taking aspirin or ibuprofen (NSAIDs) and alcohol, as this can make any swelling or bruising worse. If pain killers are required take paracetamol tablets.
For the next 2 weeks, you should avoid hot environments such as saunas, steam rooms, sunbeds and spas. For safety reasons we do not treat individuals too close to your holiday abroad, we suggest treatment is at least 2 weeks in advance.
FAQ’s
Filtered and ultra-purified natural DNA fractions from Wild salmon or trout sperm initiate your body’s natural fibroblast production. This results in increased collagen production, thicker and healthier skin, reduction in fine lines and wrinkles, and younger youthful skin.
The DNA polymer is extracted from wild salmon or trout using advanced purification and high-temperature sterilisation techniques. The result is a sterile injectable gel containing polymerised and purified natural polynucleotides.
Polynucleotides work by repairing and revitalizing skin cells. When injected into the skin, they help to stimulate collagen production, boost hydration, and improve microcirculation. This leads to firmer, smoother, and more elastic skin.
Polynucleotides have a skin regeneration and stimulating action to enhance the suppleness and quality of the skin, whereas Profhilo is pure hyaluronic acid for moisture retention. Polynucleotides are great for ageing skin, a natural way to reduce fine lines and wrinkles.
Polynucleotides revitalise your skin from the inside!! This is the latest revolutionary tool in regenerative medicine. In our clinic, polynucleotides for under-eye, tear troughs, and eye bags are very popular. Over time we lose fat and tissue under our eyes causing dark circles and eye bags, this treatment enhances the skin firmness, elasticity, dark circles, eye bags and hollowness around the eyes reducing the need for tear trough fillers.
Polynucleotides can be used to treat a large variety of areas such as:
- Upper and Lower eyelids
- Eyebags
- Tear Trough
- Face
- Neck
- Decollete
- Hands
- Arms
- Knees
- Abdomen
- Inner Thighs
- Hair Restoration
- Intimate Area
Polynucleotide treatment is suitable for patients looking for non-surgical treatment to reduce the signs of ageing and improve the quality of their skin.
During your consultation, the medical aesthetics practitioner will take a detailed medical history to ensure you have no conditions that might increase the risk of unwanted side effects.
The product is derived from Salmon or Trout, if you are allergic to fish or Vegetarian/Vegan the treatment may not be suitable. Patients with certain medical conditions or auto-immune disorders is not suitable for treatment.
Anyone under the age of 18, pregnant or breast feeding or has an active skin infection or herpes.
During the procedure, the practitioner will cleanse the treatment area and apply a topical anaesthetic if needed. The polynucleotides are then injected into the skin using fine needles. The process typically takes 30-60 minutes, depending on the area being treated.
The number of sessions will vary for individuals depending on your skin condition and desired outcome. For best results, 3 to 5 sessions are recommended every 4 weeks. Some clients may see improvements after one treatment whilst others may benefit from several treatments to optimise the regeneration effects. To maintain the desired effects, you will require maintenance treatment, a single injection every 3 or 4 months.
Preparation is minimal, but it’s advised to avoid blood-thinning medications, aspirin, Ibuprofen (NSAID) and supplements a few days before the procedure to reduce the risk of bruising. Your practitioner will provide specific instructions during your consultation.
Depending on the clients age, lifestyle, skin type and the severity of their skin troubles, the length of the treatment and effects may differ.
After treatment, clients usually see initial improvements and the effects last for 6-12 months. To get and sustain the intended outcomes, two to three sessions are required followed by regular maintenance treatments to extend the benefits of the polynucleotide skin rejuvenation.
With the treatment, you can expect to see increased skin firmness and overall improvement in skin quality. The results are not instant, after the first treatment clients should see positive changes to the skin within 3 weeks. The product continues to work for the first 12 weeks and continues to improve with time. To maximise the results, the second and third treatments will further enhance the overall outcome.
Generally, the side effects are minimal and temporary. Post-treatment the treated area may be red, swollen, with mild bruising or slight discomfort at the injection sites, it may feel warm or heat radiating from the area. These effects usually resolve in 1-3 days. Bruising can take up to 2 weeks to clear.
YES, the polynucleotide Plinest range is a highly purified and sterilised licensed source, the production is regulated and the manufacturer meets the CE standards of safety. All the protein molecules are removed, so there is no risk of allergy.
Polynucleotide skin rejuvenation is considered safe when performed by a qualified and experienced practitioner. The polynucleotides used are biocompatible, meaning they naturally integrate with the body’s tissues, minimizing the risk of adverse reactions.
The science is evidence-based and there are multiple published scientific papers demonstrating safety and efficacy in medicine for the treatment of tissue injury and in aesthetics.
Downtime is minimal. You may experience mild redness, swelling, or bruising at the injection sites, but these side effects usually subside within a few days. Most patients can return to their normal activities 24 hours after the procedure.
Post-treatment care includes avoiding direct sun exposure, strenuous exercise, and harsh skincare products for a few days. Applying ice packs and keeping the treated area clean can help with any swelling or redness.
Allergic reactions are very unlikely as the particles of DNA are highly purified and, therefore can be safely injected in those individuals who have allergies, including seafood.
YES, polynucleotide rejuvenation can be safely combined with other aesthetic treatments, such as hyaluronic acid fillers, Botox, or laser therapies, to enhance overall results. We can create a personalised treatment plan based on your needs.
You can easily book a consultation through our website or by calling us on 07955356696. Alternatively, contact us via Instagram Endlessaeathetics_1.
Our team is here to help you on your journey to revitalise youthful skin.
Polynucleotide Skin Rejuvenation Evidence-based References and Research:
- Collangelo MT. Govoni P, Beletti s, Squadrito F, Guizzardi S, Galli C. Polynucleotide biogel enhances tissue repair, matrix desposition and organization. J. of Biological Regulators & Homeostatic Agents. 2021; Vol.35 (1): 355-362. https://pubmed.ncbi.nlm.nih.gov/33480222/
- Cavallini M, Bartoletti E, Maioli L, Massirone A, Pia Palmieri I, Papagni M et al. Consensus report on the use of PN-HPT (polynucleotides highly purified technology) in aesthetic medicine. J CosmetDermatol. 2021 Mar. 20 (3): 922- 928. doi: 10.11.11/jocd.13679. Epub 2020 Sept. 21. PMID: 32799391; PMCID: PMC7984045.
https://pubmed.ncbi.nlm.nih.gov/32799391/ - Araco A, Araco F. Preliminary Prospective and Randomized Study of Highly Purified Polynucleotide vs Placebo in Treatment of Moderate to Severe Acne scars. Aesthet Surg J. 2021 Jun. 14; 41 https://pubmed.ncbi.nlm.nih.gov/33755110/
- Araco, A., Araco, F. and Raichi, M. (2022). Clinical efficacy and safety of polynucleotides highly purified technology ( PN‐HPT ®) and cross‐linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study. Journal of Cosmetic Dermatology, 22(1), pp.146–155. https://pubmed.ncbi.nlm.nih.gov/35531796/
